Hodgkin-Huxley equations

This model was created by Dr. John Fowler, of Texas Tech University Health Sciences Center, and implements the Hodgkin-Huxley equations describing currents across a neuronal membrane that contribute to the action potential. Hodgkin and Huxley published this model in 1952 and received the Nobel Prize in Physiology/Medicine, in part for this work, in 1963. Dr. Fowler has added an additional conductance from work by Connor and Stevens, 1971.

This graph shows a simulated action potential triggered by an injection of current at t=10 msec. Using the model, the underlying currents can also be graphed to determine their contribution to the action potential.

Download the model file and explore its behaviour, perhaps using Simile’s plotter, which is set-up by the included display configuration file.

We are grateful to John C. Fowler, PhD, Physiology Department, Texas Tech University Health Sciences Center for permission to distribute this model. Please contact Dr. Fowler with any comments on the model.